Best Practices Compute Environment Data Management | 3 Min Read
Streamlining Protein Structure Management with CCG PSILO: Supporting Biotechs and Pharmas of All Sizes
Phil Eschallier
CTO
October 22, 2024

Managing and analyzing macromolecular and protein-ligand structural data is a crucial yet challenging task in the complex world of Life Sciences Research. To address this need, RCH Solutions brings extensive expertise in deploying and managing Chemical Computing Group’s (CCG) PSILO platform to streamline the protein structure management processes for Biotech and Pharma companies of all sizes.

Whether for startups, mid-size, or global players, RCH Solutions ensures that customers maximize the efficiency and effectiveness of their structural data management through seamless implementation, support, and ongoing optimization of PSILO. 

What is PSILO? 

PSILO, or Protein Silo, is a sophisticated database system designed by CCG to provide a consolidated repository for proprietary and public macromolecular and protein-ligand structural information. It is tailored to meet the needs of Research organizations by offering a systematic way to register, annotate, track, and disseminate structural data derived from experimental and computational sources. 

Key Features of PSILO 

  • Centralized Data Repository: PSILO centralizes structural data from crystallographic, NMR, and computational sources, making it easy for Researchers to ensure timely access to critical information. 
  • PSILO Families: Curated collections of protein structures, including critical structural motifs, are automatically updated with new public and proprietary structures, ensuring the latest data is available. 
  • Integration with MOE: Seamless integration with CCG’s Molecular Operating Environment (MOE) ensures continuous access to updated data for Research and drug design purposes. 
  • Advanced Search and Analysis Tools: PSILO’s bioinformatics and cheminformatics tools enable detailed searches, data analysis, and structure visualization, supported by a federated database architecture. 
  • Collaborative Features: Version control, commenting, and deposit validation promote collaboration and continuous improvement in data quality across Research teams. 

Benefits of Using PSILO with RCH Solutions’ Expertise 

As an experienced scientific computing service provider, RCH Solutions specializes in helping Biotech and Pharma companies of all sizes optimize PSILO for maximum impact. 

  • Enhanced Data Accessibility: RCH Solutions ensures a smooth implementation of PSILO, centralizing data and simplifying access, reducing Research delays. 
  • Improved Data Quality: With RCH’s tailored support, organizations can leverage PSILO’s version control and collaborative tools to maintain the accuracy and reliability of their structural data. 
  • Streamlined Research Processes: RCH’s expertise ensures that the integration between PSILO and MOE operates efficiently, enabling faster, more productive Research workflows. 
  • Secure Data Management: RCH Solutions adheres to the highest IT best practices to safeguard sensitive protein structure data, ensuring secure data management. 
  • Scalable Solutions: Whether managing data for a startup or a global Pharma organization, RCH Solutions helps scale PSILO’s capabilities to meet evolving Research needs. 

General Applications and Use Cases 

  • Drug Discovery and Design: Pharmaceutical Researchers can quickly identify drug targets and design molecules using up-to-date structural data managed through PSILO. 
  • Biotech Development: Biotech companies streamline the development of innovative solutions by leveraging PSILO’s robust search and analysis tools. 
  • Collaborative Research Projects: PSILO’s collaborative features and RCH Solutions’ support allow Research teams across sites to work more cohesively on improving the quality of structural data. 

Conclusion 

RCH Solutions’ expertise with PSILO ensures that Biotech and Pharma companies of all sizes can effectively manage and utilize protein-ligand and macromolecular structural data. By centralizing, organizing, and securing structural information, RCH Solutions enhances the benefits of CCG’s PSILO platform, driving more efficient workflows, fostering collaboration, and advancing scientific Research. Whether a company is focused on drug discovery, innovation, or collaborative Research, RCH Solutions ensures that their PSILO deployment is fine-tuned and right-sized for optimal performance, empowering scientists to focus on the science and their next big breakthrough. 

Let’s chat! For more information about optimizing or leveraging CCG PSILO at your Biotech or Pharma, get in touch with our team at www.rchsolutions.com or marketing@rchsolutions.com.  

 

 

Sources: 

Chemical Computing Group (CCG) | Computer-Aided Molecular Design 

Chemical Online 

PSILO® – Structure Database – CCG Video Library 

 

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Phil Eschallier

With more than 25 years of experience as a managerial and technical computing professional, Phil currently leads RCH’s Managed Services capabilities and is responsible for all elements of the customer experience.